ea0034p397 | Thyroid | SFEBES2014
Read Martin
, Longman Jo
, Fletcher Alice
, Smith Vicki
, Watkins Rachel
, Modasia Bhavika
, Poole Vikki
, Imruetaicharoenchoke Waraporn
, Franklyn Jayne
, Boelaert Kristien
, McCabe Christopher
Dysregulation of the processing and stability of mRNA encoding oncogenes or tumour suppressor proteins is a critical event in the pathogenesis of cancer. Previously, we demonstrated that the proto-oncogene PTTG-binding factor (PBF) is overexpressed in thyroid, pituitary and breast tumours. Critically, high PBF expression is associated with reduced disease-specific survival in thyroid cancer. However, the mechanisms responsible for regulating PBF expression are unknown. In this...